Structural and functional properties of human α-thrombin, phosphopyridoxylated α-thrombin, and γT-thrombin
نویسندگان
چکیده
منابع مشابه
Structural and Functional Properties of Human a-Thrombin, Phosphopyridoxylated a-Thrombin, and yT-Thrombin IDENTIFICATION OF LYSYL RESIDUES IN a-THROMBIN THAT ARE CRITICAL FOR HEPARIN AND FIBRIN(0GEN) INTERACTIONS*
a-Thrombin derivatives obtained either by site-specific modification at lysyl residues (phosphopyridoxylated) or by limited trypsinolysis (yT-thrombin) were compared to correlate structural modifications with the functional reactivity toward fibrin(ogen) and heparin. a-Thrombin phosphopyridoxylated in the absence of heparin (unprotected) showed approximately 2 mol of label incorporated/mol of t...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)51482-4